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Cutting edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients

Abstract:

Regulatory macrophages (M regs) were administered to two living-donor renal transplant recipients. Both patients were minimized to low-dose tacrolimus monotherapy within 24 wk of transplantation and subsequently maintained excellent graft function. After central venous administration, most M regs remained viable and were seen to traffic from the pulmonary vasculature via the blood to liver, spleen, and bone marrow. By 1 y posttransplantation, both patients displayed patterns of peripheral blo...

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Publisher copy:
10.4049/jimmunol.1100762

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Journal:
Journal of Immunology More from this journal
Volume:
187
Issue:
5
Pages:
2072-2078
Publication date:
2011-09-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Pubs id:
pubs:179837
UUID:
uuid:f7b84c9a-cfc4-4ff0-9cb8-3b71a6e10ba7
Local pid:
pubs:179837
Source identifiers:
179837
Deposit date:
2012-12-19

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