An immune basis for malaria protection by the sickle cell trait
Background: Malaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism of this resistance remains the subject of considerable debate. While it probably involves innate factors such as the reduced ability of Plasmodium falciparum parasites to grow and multiply in HbAS erythrocytes, recent observations suggest that it might also involve the accelerated acquisition of malaria-specific immun...Expand abstract
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- Williams et al.
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- Citation: Williams, T. N. et al. (2005). 'An immune basis for malaria protection by the sickle cell trait', PLoS Medicine, 2(5): e128. [Available at http://medicine.plosjournals.org]. Copyright 2005 Williams et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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