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An immune basis for malaria protection by the sickle cell trait

Abstract:

Background: Malaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism of this resistance remains the subject of considerable debate. While it probably involves innate factors such as the reduced ability of Plasmodium falciparum parasites to grow and multiply in HbAS erythrocytes, recent observations suggest that it might also involve the accelerated acquisition of malaria-specific immun...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.0020128

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Institution:
"University of Oxford", "Kenya Medical Research Institute/ Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya"
Department:
Medical Sciences Division - Paediatrics,Department of
Role:
Author
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Institution:
"Kenya Medical Research Institute/ Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya"
Role:
Author
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Institution:
"National Blood Service - Oxford, John Radcliffe Hospital, Oxford", "University of Oxford"
Research group:
Blood Research Group
Department:
Medical Sciences Division - Clinical Laboratory Sciences
Role:
Author
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Institution:
"London School of Hygiene and Tropical Medicine"
Department:
Medical Research Council Tropical Epidemiology Group
Role:
Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Molecular Medicine,Weatherall Institute of
Role:
Author
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Funding agency for:
Thomas N. Williams
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Funding agency for:
David J. Weatherall
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Funding agency for:
Kevin Marsh
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
2
Issue:
5
Pages:
Article: e128
Publication date:
2005-05-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:f7b44c21-c306-43f9-b650-1015fa26b254
Local pid:
ora:2396

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