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Effect of high-dose or split-dose artesunate on parasite clearance in artemisinin-resistant falciparum malaria.

Abstract:

BACKGROUND: The emergence of Plasmodium falciparum resistance to artemisinins on the Cambodian and Myanmar-Thai borders poses severe threats to malaria control. We investigated whether increasing or splitting the dose of the short-half-life drug artesunate improves parasite clearance in falciparum malaria in the 2 regions. METHODS: In Pailin, western Cambodia (from 2008 to 2010), and Wang Pha, northwestern Thailand (2009-2010), patients with uncomplicated falciparum malaria were randomized to...

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Publisher copy:
10.1093/cid/cis958

Authors


Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America More from this journal
Volume:
56
Issue:
5
Pages:
e48-e58
Publication date:
2013-03-01
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Language:
English
Keywords:
Pubs id:
pubs:363941
UUID:
uuid:f7ab05c0-424c-4914-8096-0e9288b55511
Local pid:
pubs:363941
Source identifiers:
363941
Deposit date:
2013-11-16

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