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Journal article

Toll-like receptor 3 is a therapeutic target for pulmonary hypertension

Abstract:
Rationale: Pulmonary arterial hypertension (PAH) is characterized by vascular cell proliferation and endothelial cell apoptosis. Toll-like receptor 3 (TLR3) is a receptor for double-stranded RNA and has been recently implicated in vascular protection. Objective: The goal was to study the expression and role of TLR3 in PAH and to determine whether a TLR3 agonist reduces Pulmonary Hypertension in preclinical models. Methods: Lung... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1164/rccm.201707-1370OC

Authors


Publisher:
American Thoracic Society
Journal:
American Journal of Respiratory and Critical Care Medicine More from this journal
Volume:
199
Issue:
2
Pages:
199–210
Publication date:
2018-09-13
Acceptance date:
2018-07-03
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
Keywords:
Pubs id:
pubs:909584
UUID:
uuid:f799795e-53b0-49c7-9875-f47dba6848d4
Local pid:
pubs:909584
Source identifiers:
909584
Deposit date:
2018-08-23

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