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Antibody and HIV-1 gp120 recognition of CD4 undermines the concept of mimicry between antibodies and receptors.

Abstract:

It has been proposed that antibodies can mimic the binding of a receptor to its ligand and that anti-idiotype antibodies raised against such antibodies can be used to identify the receptor. A large number of antibodies have been raised against CD4, the receptor on T cells for the envelope glycoprotein gp120 of the human immunodeficiency virus, and the site at which gp120 binds to CD4 has been delineated. It has therefore become possible to contrast the fine specificities of a natural ligand (...

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Publication status:
Published

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Publisher copy:
10.1038/358076a0

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Schockmel, GA More by this author
Healey, DG More by this author
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Journal:
Nature
Volume:
358
Issue:
6381
Pages:
76-79
Publication date:
1992-07-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:f78f28b9-333b-44ca-a8e7-c22e803f0f79
Source identifiers:
28939
Local pid:
pubs:28939

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