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Regionally localized thinning of the cerebral cortex in schizophrenia.

Abstract:

BACKGROUND: Schizophrenia is characterized by small reductions in cortical gray matter volume, particularly in the temporal and prefrontal cortices. The question of whether cortical thickness is reduced in schizophrenia has not been addressed using magnetic resonance imaging (MRI) techniques. Our objectives were to test the hypothesis that cortical thinning in patients with schizophrenia (relative to control subjects) is greater in temporal and prefrontal regions of interest (ROIs) than in c...

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Publisher copy:
10.1001/archpsyc.60.9.878

Authors


Kuperberg, GR More by this author
Broome, MR More by this author
McGuire, PK More by this author
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Journal:
Archives of general psychiatry
Volume:
60
Issue:
9
Pages:
878-888
Publication date:
2003-09-05
DOI:
EISSN:
1538-3636
ISSN:
0003-990X
URN:
uuid:f78d516a-498e-4a72-9109-0d1d37dfea56
Source identifiers:
403473
Local pid:
pubs:403473

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