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Journal article

APC and the three-hit hypothesis.

Abstract:

The seminal 'two-hit hypothesis' implicitly assumes that bi-allelic tumour suppressor gene (TSG) mutations cause loss of protein function. All subsequent events in that tumour therefore take place on an essentially null background for that TSG protein. We have shown that the two-hit model requires modification for the APC TSG, because mutant APC proteins probably retain some function and the two hits are co-selected to produce an optimal level of Wnt activation. We wondered whether the optima...

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Publication status:
Published

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Publisher copy:
10.1038/onc.2008.361

Authors


Segditsas, S More by this author
Howarth, K More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Journal:
Oncogene
Volume:
28
Issue:
1
Pages:
146-155
Publication date:
2009-01-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:f78b4257-d913-459b-bcf3-5867b907c243
Source identifiers:
72272
Local pid:
pubs:72272

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