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Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.

Abstract:

To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS) including 3,558 subjects from the TwinsUK and BRIGHT cohorts in the UK and the DCCT/EDIC cohort from North America. Five loci were significantly associated with QT interval at P<1x10(-6). To validate these findings we performed an in silico c...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0006138

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Journal:
PloS one More from this journal
Volume:
4
Issue:
7
Pages:
e6138
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:f78a5f9b-1e1f-4419-8f8c-791be13b926c
Local pid:
pubs:105106
Source identifiers:
105106
Deposit date:
2012-12-19

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