Regulatory T cells: potential in organ transplantation.

Journal article

Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune responsiveness after organ or cell transplantation. In many settings, immunoregulatory activity is enriched in CD4+ T cells that express high levels of CD25, and common mechanisms appear to be responsible for the activity of regulatory T cells in both transplantation and the control of reactivity to self-antigens.

Authors: Wood, K; Luo, S; Akl, A

• Publication status: Published
• Journal: Transplantation
• Volume: 77
• Issue: 1 Suppl
• Pages: S6-S8
• Publication date: 2004-01-01
• DOI: 10.1097/01.tp.0000106477.70852.29
• EISSN: 1534-6080
• ISSN: 0041-1337
• Language: English
• Keywords: Humans; Isoantigens; Organ Transplantation; Transplantation Tolerance; Cytokines; T-Lymphocytes, Regulatory; T-Lymphocytes