Journal article icon

Journal article

Signalling cross talk of the HIF system: involvement of the FIH protein.

Abstract:

Cellular and systemic oxygen homeostasis is regulated by an oxygen-sensitive signalling pathway centred on a transcription factor known as Hypoxia Inducible Factor (HIF). Regulation of HIF activity and protein stability is mediated by a family of hydroxylases that act as oxygen sensors due to the dependence of the hydroxylation reaction on oxygen. The transcriptional activity of HIF is at least in part determined by asparaginyl hydroxylation by Factor Inhibiting HIF (FIH) of a C-terminal resi...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.2174/138161209789649448

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Current pharmaceutical design
Volume:
15
Issue:
33
Pages:
3904-3907
Publication date:
2009-01-01
DOI:
EISSN:
1873-4286
ISSN:
1381-6128
Source identifiers:
74006
Language:
English
Keywords:
Pubs id:
pubs:74006
UUID:
uuid:f77f5fde-e412-4c6a-a85c-de52b675f55c
Local pid:
pubs:74006
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP