Association of autoimmunity and cicatricial pemphigoid: is there an immunogenetic basis?

Journal article

A group of 34 patients with cicatricial pemphigoid was investigated for the presence of autoimmune disorders. Thirty-two percent of patients had autoimmune disease compared with 7% in the control population, a highly significant difference (p less than 0.002). Circulating autoantibodies were also significantly more common in patients (p less than 0.05). Twenty-four patients with cicatricial pemphigoid were typed for HLA. A statistically significant increase in the frequency of DR4 and DQw3 antigens was observed in these patients. These findings suggest a possible genetic basis for the autoimmune association and predisposition for development of cicatricial pemphigoid.

Authors: Nayar, M; Wojnarowska, F; Venning, V; Taylor, C

• Publication status: Published
• Journal: Journal of the American Academy of Dermatology
• Volume: 25
• Issue: 6 Pt 1
• Pages: 1011-1015
• Publication date: 1991-12-01
• DOI: 10.1016/0190-9622(91)70299-H
• EISSN: 1097-6787
• ISSN: 0190-9622
• Language: English
• Keywords: Male; Skin; Adult; Middle Aged; Anemia, Pernicious; Pemphigoid, Benign Mucous Membrane; HLA-DQ Antigens; Adolescent; Female; Case-Control Studies; Aged, 80 and over; Aged; Autoantibodies; Immunogenetics; Autoimmune Diseases; Humans; HLA-DR4 Antigen