Re-evaluating a test of the heterogeneity explanation for mortality plateaus.

Journal article

[Drapeau, M.D., Gass, E.K., Simison, M.D., Mueller, L.D., Rose, M.R., 2000. Testing the heterogeneity theory of late-life mortality plateaus by using cohorts of Drosophila melanogaster, Experimental Gerontology, 35 71-84.] tested, in populations of Drosophila melanogaster, a prediction of the heterogeneity explanation for mortality plateaus. They concluded that heterogeneity could not explain their results. We contend here that the statistical analysis was flawed. It was declared that there was no difference between the mortality plateaus of three different strains, on the basis of averaged outcomes. In fact, the results for the different strains were quite different. Most trials showed the expected lowering of the mortality plateaus for the flies selected for robustness, but these effects were washed out by a small number of very large opposing deviations. There is ample reason to believe that the opposing deviations are artifacts of fitting an overly restrictive hazard-rate model. When we fit more appropriate models, the evidence points toward a rejection of the null hypothesis (of identical plateaus), hence toward modest support for the heterogeneity explanation.

Authors: Steinsaltz, D

• Publication status: Published
• Journal: Experimental gerontology
• Volume: 40
• Issue: 1-2
• Pages: 101-113
• Publication date: 2005-01-01
• DOI: 10.1016/j.exger.2004.11.010
• EISSN: 1873-6815
• ISSN: 0531-5565
• Language: English
• Keywords: Artifacts; Models, Statistical; Male; Genetic Heterogeneity; Animals; Longevity; Female; Drosophila melanogaster; Species Specificity