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Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment.

Abstract:

Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimer's disease (AD)? One approach is to modify nongenetic risk factors, for instance by lowering elevated plasma homocysteine using B vitamins. In an initial, randomized controlled study on elderly subjects with increased dementia risk (mild cognitive impairment according to 2004 Petersen criteria), we showed that high-dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1301816110

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
de Jager, CA More by this author
Nichols, TE More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
23
Pages:
9523-9528
Publication date:
2013-06-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:f76c79f8-7a62-4f20-b99a-98a9cff6c3de
Source identifiers:
401176
Local pid:
pubs:401176

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