Journal article
Tenascin-C suppresses Rho activation.
- Abstract:
-
Cell binding to extracellular matrix (ECM) components changes cytoskeletal organization by the activation of Rho family GTPases. Tenascin-C, a developmentally regulated matrix protein, modulates cellular responses to other matrix proteins, such as fibronectin (FN). Here, we report that tenascin-C markedly altered cell phenotype on a three-dimensional fibrin matrix containing FN, resulting in suppression of actin stress fibers and induction of actin-rich filopodia. This distinct morphology was...
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- Publisher copy:
- 10.1083/jcb.150.4.913
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Authors
Bibliographic Details
- Journal:
- Journal of cell biology
- Volume:
- 150
- Issue:
- 4
- Pages:
- 913-920
- Publication date:
- 2000-08-01
- DOI:
- EISSN:
-
1540-8140
- ISSN:
-
0021-9525
- Source identifiers:
-
225995
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:225995
- UUID:
-
uuid:f76ab66e-d0e9-4694-8d94-9d4049faa57f
- Local pid:
- pubs:225995
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2000
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