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Journal article

Tenascin-C suppresses Rho activation.

Abstract:

Cell binding to extracellular matrix (ECM) components changes cytoskeletal organization by the activation of Rho family GTPases. Tenascin-C, a developmentally regulated matrix protein, modulates cellular responses to other matrix proteins, such as fibronectin (FN). Here, we report that tenascin-C markedly altered cell phenotype on a three-dimensional fibrin matrix containing FN, resulting in suppression of actin stress fibers and induction of actin-rich filopodia. This distinct morphology was...

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Publisher copy:
10.1083/jcb.150.4.913

Authors


Journal:
The Journal of cell biology
Volume:
150
Issue:
4
Pages:
913-920
Publication date:
2000-08-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:f76ab66e-d0e9-4694-8d94-9d4049faa57f
Source identifiers:
225995
Local pid:
pubs:225995

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