Sleep-like behavior and 24 hour rhythm disruption in the Tc1 mouse model of Down syndrome.
Down syndrome is a common disorder associated with intellectual disability in humans. Amongst a variety of severe health problems, patients with Down syndrome exhibit disrupted sleep and abnormal 24 h rest/activity patterns. The transchromosomic mouse model of Down syndrome, Tc1, is a trans-species mouse model for Down syndrome, carrying most of human chromosome 21 in addition to the normal complement of mouse chromosomes and expresses many of the phenotypes characteristic of Down syndrome. T...Expand abstract
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© 2015 Medical Research Council. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley and Sons Ltd.
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