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Journal article

Sleep-like behavior and 24 hour rhythm disruption in the Tc1 mouse model of Down syndrome.

Abstract:

Down syndrome is a common disorder associated with intellectual disability in humans. Amongst a variety of severe health problems, patients with Down syndrome exhibit disrupted sleep and abnormal 24 h rest/activity patterns. The transchromosomic mouse model of Down syndrome, Tc1, is a trans-species mouse model for Down syndrome, carrying most of human chromosome 21 in addition to the normal complement of mouse chromosomes and expresses many of the phenotypes characteristic of Down syndrome. T...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/gbb.12198

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Funding agency for:
Peirson, S
More from this funder
Name:
Wellcome Trust
Funding agency for:
Peirson, S
Publisher:
Wiley
Journal:
Genes, Brain and Behavior More from this journal
Volume:
14
Issue:
2
Pages:
209–216
Publication date:
2015-02-01
DOI:
EISSN:
1601-183X
ISSN:
1601-1848
Language:
English
Keywords:
Pubs id:
pubs:502796
UUID:
uuid:f75dfc07-42ce-4038-9c0d-f2d3304f98bd
Local pid:
pubs:502796
Source identifiers:
502796
Deposit date:
2015-01-16

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