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Journal article

Sleep-like behavior and 24 hour rhythm disruption in the Tc1 mouse model of Down syndrome.

Abstract:

Down syndrome is a common disorder associated with intellectual disability in humans. Amongst a variety of severe health problems, patients with Down syndrome exhibit disrupted sleep and abnormal 24 h rest/activity patterns. The transchromosomic mouse model of Down syndrome, Tc1, is a trans-species mouse model for Down syndrome, carrying most of human chromosome 21 in addition to the normal complement of mouse chromosomes and expresses many of the phenotypes characteristic of Down syndrome. T...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/gbb.12198

Authors


Fisher, SP More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Funding agency for:
Peirson, SN
Publisher:
Wiley Publisher's website
Journal:
Genes, Brain and Behavior Journal website
Volume:
14
Issue:
2
Pages:
209–216
Publication date:
2015-02-05
DOI:
EISSN:
1601-183X
ISSN:
1601-1848
URN:
uuid:f75dfc07-42ce-4038-9c0d-f2d3304f98bd
Source identifiers:
502796
Local pid:
pubs:502796

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