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Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.

Abstract:

Mutations in the synaptic protein alpha-synuclein cause rare genetic forms of Parkinson's disease. Alpha-synuclein is thought to play a critical role in more common sporadic cases of Parkinson's disease as well because the protein aggregates in the hallmark intraneuronal inclusions of the disorder, Lewy bodies. To test the role of protein aggregation in the pathogenesis of Parkinson's disease, we expressed a form of alpha-synuclein with a deletion of amino acids 71-82 that is unable to aggreg...

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Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience More from this journal
Volume:
27
Issue:
12
Pages:
3338-3346
Publication date:
2007-03-01
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Language:
English
Keywords:
Pubs id:
pubs:477700
UUID:
uuid:f75bcfd2-6f88-4105-b604-01f5dbb8db82
Local pid:
pubs:477700
Source identifiers:
477700
Deposit date:
2014-08-11

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