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Mosaic HIV-1 Gag antigens can be processed and presented to human HIV-specific CD8+ T cells.

Abstract:

Polyvalent mosaic HIV immunogens offer a potential solution for generating vaccines that can elicit immune responses against genetically diverse viruses. However, it is unclear whether key T cell epitopes can be processed and presented from these synthetic Ags and recognized by epitope-specific human T cells. In this study, we tested the ability of mosaic HIV immunogens expressed by recombinant, replication-incompetent adenovirus serotype 26 vectors to process and present major HIV clade B an...

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Publisher copy:
10.4049/jimmunol.1004231

Authors


Ndhlovu, ZM More by this author
Piechocka-Trocha, A More by this author
McMullen, A More by this author
Koofhethile, KC More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
186
Issue:
12
Pages:
6914-6924
Publication date:
2011-06-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:f75946d0-4bfd-4464-b79f-1bd3b9083f66
Source identifiers:
191273
Local pid:
pubs:191273

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