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Human genome sequence variation and the influence of gene history, mutation and recombination.

Abstract:

Variation in the human genome sequence is key to understanding susceptibility to disease in modern populations and the history of ancestral populations. Unlocking this information requires knowledge of the patterns and underlying causes of human sequence diversity. By applying a new population-genetic framework to two genome-wide polymorphism surveys, we find that the human genome contains sizeable regions (stretching over tens of thousands of base pairs) that have intrinsically high and low ...

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Publication status:
Published

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Publisher copy:
10.1038/ng947

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Journal:
Nature genetics More from this journal
Volume:
32
Issue:
1
Pages:
135-142
Publication date:
2002-09-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Language:
English
Keywords:
Pubs id:
pubs:103263
UUID:
uuid:f7553f42-02d1-4d70-8c99-a1c51f63919d
Local pid:
pubs:103263
Source identifiers:
103263
Deposit date:
2012-12-19

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