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Crystallization and preliminary X-ray analysis of CrgA, a LysR-type transcriptional regulator from pathogenic Neisseria meningitidis MC58.

Abstract:

Although LysR-type regulators (LTTRs) represent the largest family of transcriptional regulators in bacteria, the full-length structure of only one annotated LTTR (CbnR) has been deposited in the PDB. CrgA, a LTTR from pathogenic Neisseria meningitidis MC58, which is up-regulated upon bacterial cell contact with human epithelial cells, has been cloned, purified and crystallized. Crystals of full-length CrgA were obtained after buffer screening with a thermal shift assay and concentration with...

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Publication status:
Published

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Publisher copy:
10.1107/s1744309108024068

Authors


Sainsbury, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Journal:
Acta crystallographica. Section F, Structural biology and crystallization communications
Volume:
64
Issue:
Pt 9
Pages:
797-801
Publication date:
2008-09-05
DOI:
EISSN:
1744-3091
ISSN:
1744-3091
URN:
uuid:f750c9d0-0969-4d49-8bd2-92bd8a6ba029
Source identifiers:
11661
Local pid:
pubs:11661

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