Retinoblastoma: treatment and survival in Great Britain 1963 to 2002.

Journal article

AIM: This paper describes the treatment and survival of 1576 children with retinoblastoma in Great Britain diagnosed 1963-2002. METHODS: Survival rates were analysed according to period of diagnosis and tumour laterality. RESULTS: Survival was calculated by calendar period of diagnosis, 1963-1982 and 1983-2002. For both unilateral and bilateral retinoblastoma, survival improved between the two periods. The survival curves for the two periods were significantly different: for unilateral retinoblastoma p<0.00001, for bilateral p<0.01. For unilateral cases, the estimated 5-year survival rates rose from 85% for those diagnosed in 1963-1967 to 97% for those diagnosed in 1998-2002. The equivalent rates for bilateral cases were 88% and 100%. CONCLUSION: Survival rates were already high at the start of the study period. They increased with changes in treatment regimens.

Authors: MacCarthy, A; Birch, J; Draper, G; Hungerford, J; Kingston, J

• Publication status: Published
• Journal: British journal of ophthalmology
• Volume: 93
• Issue: 1
• Pages: 38-39
• Publication date: 2009-01-01
• DOI: 10.1136/bjo.2008.139626
• EISSN: 1468-2079
• ISSN: 0007-1161
• Language: English
• Keywords: Antineoplastic Combined Chemotherapy Protocols; Child; Adolescent; Retinoblastoma; Child, Preschool; Humans; Survival Rate; Male; Survival Analysis; Eye Enucleation; Infant, Newborn; Infant; Great Britain; Registries; Retinal Neoplasms; Female