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Journal article

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.

Abstract:

AIMS: Clinical markers of cardiac autonomic function, such as heart rate and response to exercise, are important predictors of cardiovascular risk. Tetrahydrobiopterin (BH4) is a required cofactor for enzymes with roles in cardiac autonomic function, including tyrosine hydroxylase and nitric oxide synthase. Synthesis of BH4 is regulated by GTP cyclohydrolase I (GTPCH), encoded by GCH1. Recent clinical studies report associations between GCH1 variants and increased heart rate, but the mechanis...

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Publication status:
Published

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Publisher copy:
10.1093/cvr/cvs005

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Institution:
University of Oxford
Division:
MSD
Role:
Author
Journal:
Cardiovascular research More from this journal
Volume:
93
Issue:
4
Pages:
694-701
Publication date:
2012-03-01
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Language:
English
Keywords:
Pubs id:
pubs:237264
UUID:
uuid:f74e5ec9-8674-478f-9134-335a497636d2
Local pid:
pubs:237264
Source identifiers:
237264
Deposit date:
2012-12-19

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