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Defining the minimal requirements for papilloma viral E6-mediated inhibition of human p53 activity in fission yeast.

Abstract:

The majority of human anogenital carcinomas show evidence of papillomavirus infection. To facilitate viral replication, viruses disable key cellular responses which would otherwise precipitate cell suicide. An obligate factor in one such response is the p53 tumour suppressor protein. p53 gene mutation is an infrequent event in anogenital cancer, apparently due to the action of HPV E6 protein, which inhibits wild-type p53 function by stimulating the degradation of p53 protein. p53 is required ...

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Publisher copy:
10.1038/sj.onc.1201848

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Oncogene
Volume:
16
Issue:
13
Pages:
1759-1765
Publication date:
1998-04-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:f741ceff-7fef-45ec-a92d-cd864f8764fa
Source identifiers:
428065
Local pid:
pubs:428065

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