- Abstract:
-
The majority of human anogenital carcinomas show evidence of papillomavirus infection. To facilitate viral replication, viruses disable key cellular responses which would otherwise precipitate cell suicide. An obligate factor in one such response is the p53 tumour suppressor protein. p53 gene mutation is an infrequent event in anogenital cancer, apparently due to the action of HPV E6 protein, which inhibits wild-type p53 function by stimulating the degradation of p53 protein. p53 is required ...
Expand abstract - Publisher copy:
- 10.1038/sj.onc.1201848
-
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- Journal:
- Oncogene
- Volume:
- 16
- Issue:
- 13
- Pages:
- 1759-1765
- Publication date:
- 1998-04-05
- DOI:
- EISSN:
-
1476-5594
- ISSN:
-
0950-9232
- URN:
-
uuid:f741ceff-7fef-45ec-a92d-cd864f8764fa
- Source identifiers:
-
428065
- Local pid:
- pubs:428065
- Copyright date:
- 1998
Journal article
Defining the minimal requirements for papilloma viral E6-mediated inhibition of human p53 activity in fission yeast.
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