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Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300

Abstract:
Ageing is the primary risk factor for osteoarthritis (OA). A decline in the ageing-associated process of autophagy is suggested as a potential contributor to OA development. Polyamines such as spermidine decrease during ageing, contributing to impaired autophagy and reduced cellular function. However, the role of polyamines and their effect on the regulatory mechanism governing autophagy in aged and arthritic cartilage tissue has not been established. Elucidating if polyamine regulation of autophagy is impaired during ageing and OA in chondrocytes may lead to improved treatment approaches to protect against cartilage degradation. Our results indicate that polyamine synthesis was decreased in aged and OA cartilage, along with reduced autophagy activity, evidenced by decreased autophagyrelated gene and protein expression and autophagosome formation. Importantly, spermidine treatment increased the expression of the acetyltransferase EP300, which binds to crucial autophagy proteins, Beclin1 and LC3, and elevates chondrocyte autophagy. Our data indicate spermidine prevents the ageing- and OA-related decrease in autophagy and may protect against OA development.
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Oxford college:
St Catherine's College
Role:
Author
ORCID:
0000-0001-7391-0820


Publisher:
Nature Publishing Group
Journal:
Experimental and Molecular Medicine EMM More from this journal
Volume:
50
Issue:
6
Pages:
123
Publication date:
2018-09-19
Acceptance date:
2018-06-25
DOI:
EISSN:
2092-6413
ISSN:
1226-3613


Pubs id:
pubs:918787
UUID:
uuid:f73c04d0-051f-489b-866a-bf524b284f0d
Local pid:
pubs:918787
Deposit date:
2018-09-12

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