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Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300

Abstract:

Ageing is the primary risk factor for osteoarthritis (OA). A decline in the ageing-associated process of autophagy is suggested as a potential contributor to OA development. Polyamines such as spermidine decrease during ageing, contributing to impaired autophagy and reduced cellular function. However, the role of polyamines and their effect on the regulatory mechanism governing autophagy in aged and arthritic cartilage tissue has not been established. Elucidating if polyamine regulation of au...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s12276-018-0149-3

Authors


Sacitharan, P More by this author
Bou Gharios, G More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
Botnar Research Centre
Oxford college:
St Catherines College
ORCID:
0000-0001-7391-0820
Orthopaedic Research U.K. More from this funder
European Institute of Innovation and Technology More from this funder
US-UK Fulbright Commission More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Experimental and Molecular Medicine EMM Journal website
Volume:
50
Issue:
6
Pages:
123
Publication date:
2018-09-19
Acceptance date:
2018-06-25
DOI:
EISSN:
2092-6413
ISSN:
1226-3613
Pubs id:
pubs:918787
URN:
uri:f73c04d0-051f-489b-866a-bf524b284f0d
UUID:
uuid:f73c04d0-051f-489b-866a-bf524b284f0d
Local pid:
pubs:918787

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