Journal article icon

Journal article

Ischemia-reperfusion injury accelerates human antibody-mediated transplant vasculopathy.

Abstract:

BACKGROUND: The pathogenesis of transplant vasculopathy (TV) is a multifactorial process. We hypothesized that ischemia-reperfusion injury and antibody-mediated damage contribute to the development of TV. METHODS: Human vessels were procured from nine separate donors undergoing cardiac surgery and stored in saline solution on ice until transplantation. BALB/c Rag2IL-2Rγ mice were transplanted with a human vessel graft on day 0. Purified anti-human leukocyte antigen class I antibody (W6/32), i...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1097/tp.0b013e318295ee32

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Transplantation
Volume:
96
Issue:
2
Pages:
139-145
Publication date:
2013-07-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:f734856b-ea69-467e-ada2-951456329587
Source identifiers:
414762
Local pid:
pubs:414762

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP