- Abstract:
-
BACKGROUND: The pathogenesis of transplant vasculopathy (TV) is a multifactorial process. We hypothesized that ischemia-reperfusion injury and antibody-mediated damage contribute to the development of TV. METHODS: Human vessels were procured from nine separate donors undergoing cardiac surgery and stored in saline solution on ice until transplantation. BALB/c Rag2IL-2Rγ mice were transplanted with a human vessel graft on day 0. Purified anti-human leukocyte antigen class I antibody (W6/32), i...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1097/tp.0b013e318295ee32
-
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- Journal:
- Transplantation
- Volume:
- 96
- Issue:
- 2
- Pages:
- 139-145
- Publication date:
- 2013-07-05
- DOI:
- EISSN:
-
1534-6080
- ISSN:
-
0041-1337
- URN:
-
uuid:f734856b-ea69-467e-ada2-951456329587
- Source identifiers:
-
414762
- Local pid:
- pubs:414762
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Ischemia-reperfusion injury accelerates human antibody-mediated transplant vasculopathy.
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