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Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens

Abstract:

Dopamine (DA) neurotransmission in the nucleus accumbens (NAc) is critically involved in normal as well as maladaptive motivated behaviors including drug addiction. Whether the striatal neuromodulator nitric oxide (NO) influences DA release in NAc is unknown. We investigated whether exogenous NO modulates DA transmission in NAc core and how this interaction varies depending on the frequency of presynaptic activation. We detected DA with cyclic voltammetry at carbon-fiber microelectrodes in mo...

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Publisher copy:
10.1038/npp.2011.62

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Neuropsychopharmacology
Volume:
36
Issue:
9
Pages:
1811-1822
Publication date:
2011-08-05
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
URN:
uuid:f72b9173-983b-445c-8718-ba3d5066ffbf
Source identifiers:
167724
Local pid:
pubs:167724

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