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Identifying and exploiting genes that potentiate the evolution of antibiotic resistance

Abstract:

There is an urgent need to develop novel approaches for predicting and preventing the evolution of antibiotic resistance. Here, we show that the ability to evolve de novo resistance to a clinically important β-lactam antibiotic, ceftazidime, varies drastically across the genus Pseudomonas. This variation arises because strains possessing the ampR global transcriptional regulator evolve resistance at a high rate. This does not arise because of mutations in ampR. Instead, this regulator potenti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41559-018-0547-x

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
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Funding agency for:
MacLean, RC
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Ecology and Evolution Journal website
Volume:
2
Pages:
1033–1039
Publication date:
2018-04-23
Acceptance date:
2018-03-27
DOI:
EISSN:
2397-334X
Pubs id:
pubs:831836
URN:
uri:f72b312d-5b8e-4778-9c8c-b601a2e39b17
UUID:
uuid:f72b312d-5b8e-4778-9c8c-b601a2e39b17
Local pid:
pubs:831836

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