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Journal article

Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen.

Abstract:

Type VII collagen (ColVII) is the main component of anchoring fibrils, attachment structures within the lamina densa of the basement membrane that are responsible for attachment of the epidermis to the dermis in skin. Mutations in the human ColVII gene, COL7A1, cause the severe inherited blistering disorder recessive dystrophic epidermolysis bullosa (RDEB) affecting skin and mucosae, associated with a greatly increased risk of skin cancer. In this study, we examined the effect of loss of ColV...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.042895

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Journal:
Journal of cell science
Volume:
122
Issue:
Pt 11
Pages:
1788-1799
Publication date:
2009-06-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:f7290144-b004-48d6-942c-2027769dbadf
Source identifiers:
175354
Local pid:
pubs:175354

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