- Abstract:
- After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10 -9). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10 -11. © 2012 Nature America, Inc. All rights reserved.
- Publisher copy:
- 10.1038/ng.1080
-
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- Journal:
- Nature Genetics
- Volume:
- 44
- Issue:
- 3
- Pages:
- 257-259
- Publication date:
- 2012-03-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:f727ea17-ceb7-4f5b-a43a-9d8d3b9d8bcd
- Source identifiers:
-
320788
- Local pid:
- pubs:320788
- Language:
- English
- Copyright date:
- 2012
Journal article
Common variants at 11p13 are associated with susceptibility to tuberculosis
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