Common variants at 11p13 are associated with susceptibility to tuberculosis

Journal article

After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10 -9). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10 -11. © 2012 Nature America, Inc. All rights reserved.

Authors: Thye, T; Owusu-Dabo, E; Vannberg, F; Van Crevel, R; Curtis, J

• Journal: Nature Genetics
• Volume: 44
• Issue: 3
• Pages: 257-259
• Publication date: 2012-03-01
• DOI: 10.1038/ng.1080
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English