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Common variants at 11p13 are associated with susceptibility to tuberculosis

Abstract:
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10 -9). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10 -11. © 2012 Nature America, Inc. All rights reserved.

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Publisher copy:
10.1038/ng.1080

Authors


Owusu-Dabo, E More by this author
Vannberg, FO More by this author
Van Crevel, R More by this author
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Journal:
Nature Genetics
Volume:
44
Issue:
3
Pages:
257-259
Publication date:
2012-03-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:f727ea17-ceb7-4f5b-a43a-9d8d3b9d8bcd
Source identifiers:
320788
Local pid:
pubs:320788
Language:
English

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