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Implications of HIV diversity for the HIV-1 pandemic

Abstract:

HIV-1 genetic variability within individuals and populations plays a central role in the HIV pandemic. Multiple zoonotic transmissions of SIV to humans have resulted in distinct HIV lineages in humans which have further diversified within the population over time. High rates of mutation and recombination during HIV reverse transcription create a genetic diversity in the host which is subject to selection pressures by the immune response and antiretroviral treatment. The global distribution of...

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Publisher copy:
10.1016/j.jinf.2012.10.026
Journal:
Journal of Infection More from this journal
Volume:
66
Issue:
5
Pages:
391-400
Publication date:
2013-05-01
DOI:
EISSN:
1532-2742
ISSN:
0163-4453
Language:
English
Keywords:
Pubs id:
pubs:395539
UUID:
uuid:f725ba86-a3f7-4b86-b308-9a868dea2e8b
Local pid:
pubs:395539
Source identifiers:
395539
Deposit date:
2013-11-16

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