Journal article
Longitudinal analysis of antibody cross-neutralization following Zika and dengue virus infection in Asia and the Americas
- Abstract:
- Background The four dengue virus serotypes (DENV1-4) and Zika virus (ZIKV) are related mosquito-borne flaviviruses of major importance globally. While monoclonal antibodies and plasma from DENV-immune donors can neutralize or enhance ZIKV in vitro and in small animal models, and vice versa, the extent, duration, and significance of cross-reactivity remains unknown, particularly in flavivirus-endemic regions. Methods We studied neutralizing antibodies to ZIKV and DENV1-4 in longitudinal serologic specimens through 3 years post-infection from people in Latin America and Asia with laboratory-confirmed DENV infections. We also evaluated neutralizing antibodies to ZIKV and DENV1-4 in Zika patients through 6 months post-infection. Results In Zika patients, the highest neutralizing antibody titers were to ZIKV, with low-level cross-reactivity to DENV1-4 that was greater in DENV-immune individuals. We found in primary and secondary DENV infections, neutralizing antibody titers to ZIKV were markedly lower than to the infecting DENV and heterologous DENV serotypes. Cross-neutralization was greatest in early convalescence, then ZIKV neutralization decreased, remaining at low levels over time. Conclusions Patterns of antibody cross-neutralization suggest ZIKV lies outside the DENV serocomplex. Neutralizing antibody titers can distinguish ZIKV from DENV infections when all viruses are analyzed simultaneously. These findings have implications for understanding natural immunity and vaccines.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, zip, 2.4MB, Terms of use)
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(Preview, Accepted manuscript, pdf, 2.7MB, Terms of use)
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- Publisher copy:
- 10.1093/infdis/jiy164
Authors
+ Centers for Disease Control and Prevention
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- Grant:
- Contract 00HVCLJB-2017-04191 (AdS
+ National Institutes of Health
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- Grant:
- P01AI106695(PD
- Project1PIEH
- Project2PIAdS
- Publisher:
- Oxford University Press
- Journal:
- Journal of Infectious Diseases More from this journal
- Volume:
- 218
- Issue:
- 4
- Pages:
- 536–545
- Publication date:
- 2018-04-02
- Acceptance date:
- 2018-02-06
- DOI:
- EISSN:
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1537-6613
- ISSN:
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0022-1899
- Keywords:
- Pubs id:
-
pubs:833670
- UUID:
-
uuid:f720bb17-39e2-49b1-8d41-cbb9fd13516a
- Local pid:
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pubs:833670
- Source identifiers:
-
833670
- Deposit date:
-
2018-04-05
- ARK identifier:
Terms of use
- Copyright holder:
- Montoya et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 The Authors. Published by Oxford University Press for the Infectious Diseases Society of America. This is the accepted manuscript version of the article. The final version is available online from Oxford University Press at: https://doi.org/10.1093/infdis/jiy164
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