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Journal article

Single nucleotide polymorphisms in Plasmodium falciparum V type H(+) pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms.

Abstract:

BACKGROUND: Chloroquine resistance in Plasmodium falciparum malaria has been associated with pfcrt 76T (chloroquine resistance transporter gene) and pfmdr1 86Y (multidrug resistance gene 1) alleles. Pfcrt 76T enables transport of protonated chloroquine out of the parasites digestive vacuole resulting in a loss of hydrogen ions (H(+)). V type H(+) pyrophosphatase (PfVP2) is thought to pump H(+) into the digestive vacuole. This study aimed to describe the geographic distribution of single nucle...

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Publication status:
Published

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Journal:
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Volume:
24
Pages:
111-115
Chapter number:
C
Publication date:
2014-06-05
DOI:
EISSN:
1567-7257
ISSN:
1567-1348
URN:
uuid:f71f89e7-7146-44e8-a51c-13dcd9d7b89b
Source identifiers:
458785
Local pid:
pubs:458785

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