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Brain burdens of aluminum, iron, and copper and their relationships with amyloid-β pathology in 60 human brains.

Abstract:

The deposition in the brain of amyloid-β as beta sheet conformers associated with senile plaques and vasculature is frequently observed in Alzheimer’s disease. While metals, primarily aluminum, iron, zinc, and copper, have been implicated in amyloid-β deposition in vivo, there are few data specifically relating brain metal burden with extent of amyloid pathologies in human brains. Herein brain tissue content of aluminum, iron, and copper are compared with burdens of amyloid-β, as senile plaqu...

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Publication status:
Published

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Publisher copy:
10.3233/jad-2012-120766

Authors


Polwart, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Journal of Alzheimer's disease : JAD
Volume:
31
Issue:
4
Pages:
725-730
Publication date:
2012
DOI:
EISSN:
1875-8908
ISSN:
1387-2877
URN:
uuid:f71ae28d-7334-4c92-8198-0e5a0a0a6f9b
Source identifiers:
339962
Local pid:
pubs:339962

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