Association between oral anticoagulants and COVID-19-related outcomes: a population-based cohort study

Journal article

Introduction: Little is known about the role played by anticoagulants in COVID-19. Objective: The aim of this study was to assess the impact of previous anticoagulant treatment on risk of hospitalization due to COVID-19, progression to severe COVID-19 and susceptibility to COVID-19 infection. Methods: We conducted a multiple population-based case–control study in northwest Spain, in 2020, to assess (1) risk of hospitalization: cases were all patients admitted due to COVID-19 with PCR confirmation, and controls were a random matched sample of subjects without a positive PCR; (2) progression: cases were hospitalized COVID-19 subjects, and controls were all non-hospitalized COVID-19 patients; and (3) susceptibility: cases were patients with a positive PCR (hospitalized and non-hospitalized), and the controls were the same as for the hospitalization model. Adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using a generalized linear mixed modelS

Authors: Wong, AY; Tomlinson, L; Brown, JP; Elson, W; Walker, AJ

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Royal College of General Practitioners
• Journal: British Journal of General Practice
• Volume: 72
• Issue: 720
• Pages: e456-e463
• Publication date: 2022-02-16
• DOI: 10.3399/bjgp.2021.0689
• EISSN: 1478-5242
• ISSN: 0960-1643
• Language: English
• Keywords: Causality (physics); Cohort study; Association (psychology); Prospective cohort study; MEDLINE; Cohort; Stroke (engine)