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Mechanisms driving the lactate switch in Chinese hamster ovary cells

Abstract:

The metabolism of Chinese Hamster Ovary (CHO) cells in a production environment has been extensively investigated. However, a key metabolic transition, the switch from lactate production to lactate consumption, remains enigmatic. Though commonly observed in CHO cultures, the mechanism(s) by which this metabolic shift is triggered is unknown. Despite this, efforts to control the switch have emerged due to the association of lactate consumption with improved cell growth and productivity. This r...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1002/bit.26603

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Role:
Author
ORCID:
0000-0002-5638-1813
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Role:
Author
Biotechnology and Biological Sciences Research Council More from this funder
GlaxoSmithKline More from this funder
Publisher:
Wiley Publisher's website
Journal:
Biotechnology and Bioengineering Journal website
Volume:
115
Issue:
8
Pages:
1890-1903
Publication date:
2018-04-10
Acceptance date:
2018-03-28
DOI:
EISSN:
1097-0290
ISSN:
0006-3592
Pubs id:
pubs:833871
URN:
uri:f713ef24-d559-4601-afb2-5177dca20e9b
UUID:
uuid:f713ef24-d559-4601-afb2-5177dca20e9b
Local pid:
pubs:833871

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