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Haemophilus influenzae Type b vaccine failure in children is associated with inadequate production of high-quality antibody

Abstract:

Background: Despite the excellent immunogenicity of Haemophilus influenzae type b (Hib) conjugate vaccines, breakthrough cases of Hib disease still affect a small proportion of vaccinated children in the United Kingdom. We performed a retrospective study to compare the avidity of antibody directed against the Hib polysaccharide capsule (PRP) in children who experienced Hib vaccine failure in the United Kingdom among 3 historical cohorts and with age-matched healthy control subjects. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1086/524668

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Centre for Statistics in Medicine
Role:
Author
More by this author
Institution:
"Health Protection Agency Centre for Infections"
Department:
Haemophilus Reference Unit,Respiratory and Systemic Infection Laboratory
Role:
Author
More by this author
Institution:
"National Centre for Immunisation Research and Surveillance, Sydney, Australia"
Role:
Author

Contributors

Publisher:
University of Chicago Press
Journal:
Clinical Infectious Diseases More from this journal
Volume:
46
Issue:
2
Pages:
186-192
Publication date:
2008-01-01
DOI:
ISSN:
1058-4838
Language:
English
Keywords:
Subjects:
UUID:
uuid:f709ac94-1c79-45aa-af48-47f0a372727a
Local pid:
ora:3048
Deposit date:
2009-11-10

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