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Tubular aggregates and cylindrical spirals have distinct immunohistochemical signatures

Abstract:

Tubular aggregates and cylindrical spirals are 2 distinct ultrastructural abnormalities observed in muscle biopsies that have similar histochemical staining characteristics on light microscopy. Both are found in a wide range of disorders. Recently, a number of genetic mutations have been reported in conditions with tubular aggregates in skeletal muscle. It is widely accepted that tubular aggregates arise from the sarcoplasmic reticulum, but the origin of cylindrical spirals has been less clea...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/jnen/nlw096

Authors


More from this funder
Name:
National Institute for Health Research
Funding agency for:
Healy, E
Grant:
BRC128/NS/MH5992
More from this funder
Name:
Reta Lila Weston Institute for Neurological Studies
Funding agency for:
Holton, J
More from this funder
Name:
Myositis UK
Funding agency for:
Brady, S
Holton, J
Publisher:
Oxford University Press
Journal:
Journal of Neuropathology Experimental Neurology More from this journal
Volume:
75
Issue:
12
Pages:
1171-1178
Publication date:
2016-12-07
DOI:
EISSN:
1554-6578
ISSN:
0022-3069
Language:
English
Keywords:
Pubs id:
pubs:666556
UUID:
uuid:f6fba2c8-6255-4532-8e7a-e07c2a1386e1
Local pid:
pubs:666556
Source identifiers:
666556
Deposit date:
2017-06-14

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