Intracellular C3a regulates cell proliferation in prostate epithelial cells

Conference item

While liver-derived and serum-circulating complement mediates protection against infections, recent studies demonstrate that complement C3 is also activated intracellularly in a wide range of cells and that the intracellular C3a/C3aR interaction contributes to basic processes of the cell, including normal proliferation via the mTOR/glycolysis axis. As pathological increased intracellular C3 activation contributes to abnormal cellular function in T cells, we investigated whether dysregulation of this system also applies to prostate cancer.

Authors: Yamamoto, H; Chandra, A; Seymour, L; Dasgupta, P; Kemper, C

• Publication status: Published
• Peer review status: Reviewed (other)
• Publisher: Elsevier
• Host title: 26th International Complement Workshop (ICW 2016)
• Journal: Immunobiology
• Publication date: 2016-08-01
• DOI: 10.1016/j.imbio.2016.06.171
• ISSN: 0171-2985