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Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-alpha, but not interleukin-10: possible relevance to pathophysiology of rheumatoid arthritis.

Abstract:

Previous studies in the laboratory have shown that the pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA). The mechanisms involved in regulating monocyte/macrophage cytokine production are not yet fully understood, but are thought to involve both soluble factors and cell/cell contact with other cell types. We and others have previously demonstrated that T cells activated through the T cell receptor/CD3 complex indu...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830270308

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
European journal of immunology
Volume:
27
Issue:
3
Pages:
624-632
Publication date:
1997-03-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:f6ee4b2d-2955-427d-8aba-de8ed5ba288c
Source identifiers:
481613
Local pid:
pubs:481613

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