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Measuring the content of a single liposome via electrocatalytic nano-impact “titrations”

Abstract:

We show the electrochemical determination of attomole glutathione contents within single individual liposomes at low overpotentials through mediated electron transfer using copper (II) as a catalyst for the oxidation of liposomal glutathione. A “titration-like” behaviour of individual liposomes was observed when impacting with the electrode to quantify the content within single liposomes. The nanoimpacts “titration” strategy allows the characterisation of nanoparticles containing redox inactive molecules at the single nanoparticle level.

Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
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Name:
European Research Council
Grant:
320403
Publisher:
Wiley
Journal:
ChemElectroChem More from this journal
Volume:
3
Issue:
12
Pages:
2017–2020
Publication date:
2016-07-22
Acceptance date:
2016-07-08
DOI:
EISSN:
2196-0216
Keywords:
Pubs id:
pubs:632538
UUID:
uuid:f6e3b7cb-5a72-495b-a5b6-6a83604c7582
Local pid:
pubs:632538
Source identifiers:
632538
Deposit date:
2016-07-08

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