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Journal article

Role of T cells in inflammation caused by adenovirus vectors in the brain.

Abstract:

In many organs, E1-deleted human adenovirus vectors trigger antiviral T cell responses which limit the duration of vector-encoded gene expression. When injected into the brain, however, long-term expression is possible in spite of the ensuing inflammatory response. To examine the role of T cells in the immune response in the brain, monoclonal antibodies were used to systemically deplete CD4+ and/or CD8+ T cell subsets from mice at the time of vector injection. The early phase of the inflammat...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Gene therapy More from this journal
Volume:
3
Issue:
7
Pages:
644-651
Publication date:
1996-07-01
EISSN:
1476-5462
ISSN:
0969-7128
Language:
English
Keywords:
Pubs id:
pubs:113540
UUID:
uuid:f6e218a1-6731-441c-85f0-706dd3a3732f
Local pid:
pubs:113540
Source identifiers:
113540
Deposit date:
2013-11-17

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