Journal article
Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover.
- Abstract:
-
Both end structures of eukaryotic mRNAs, namely the 5' cap and 3' poly(A) tail, are necessary for transcript stability, and loss of either is sufficient to stimulate decay. mRNA turnover is classically thought to be initiated by deadenylation, as has been particularly well described in Saccharomyces cerevisiae. Here we describe two additional, parallel decay pathways in the fission yeast Schizosaccharomyces pombe. First, in fission yeast mRNA decapping is frequently independent of deadenylati...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/nsmb.1601
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Authors
Bibliographic Details
- Journal:
- Nature structural and molecular biology
- Volume:
- 16
- Issue:
- 6
- Pages:
- 616-623
- Publication date:
- 2009-06-01
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- Source identifiers:
-
5806
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:5806
- UUID:
-
uuid:f6df6f49-c320-451c-8c90-e7cc12d651f8
- Local pid:
- pubs:5806
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2009
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