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Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover.

Abstract:

Both end structures of eukaryotic mRNAs, namely the 5' cap and 3' poly(A) tail, are necessary for transcript stability, and loss of either is sufficient to stimulate decay. mRNA turnover is classically thought to be initiated by deadenylation, as has been particularly well described in Saccharomyces cerevisiae. Here we describe two additional, parallel decay pathways in the fission yeast Schizosaccharomyces pombe. First, in fission yeast mRNA decapping is frequently independent of deadenylati...

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Publication status:
Published

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Publisher copy:
10.1038/nsmb.1601

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Nature structural and molecular biology
Volume:
16
Issue:
6
Pages:
616-623
Publication date:
2009-06-05
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
URN:
uuid:f6df6f49-c320-451c-8c90-e7cc12d651f8
Source identifiers:
5806
Local pid:
pubs:5806

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