- Abstract:
-
Both end structures of eukaryotic mRNAs, namely the 5' cap and 3' poly(A) tail, are necessary for transcript stability, and loss of either is sufficient to stimulate decay. mRNA turnover is classically thought to be initiated by deadenylation, as has been particularly well described in Saccharomyces cerevisiae. Here we describe two additional, parallel decay pathways in the fission yeast Schizosaccharomyces pombe. First, in fission yeast mRNA decapping is frequently independent of deadenylati...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nsmb.1601
-
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- Journal:
- Nature structural and molecular biology
- Volume:
- 16
- Issue:
- 6
- Pages:
- 616-623
- Publication date:
- 2009-06-05
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- URN:
-
uuid:f6df6f49-c320-451c-8c90-e7cc12d651f8
- Source identifiers:
-
5806
- Local pid:
- pubs:5806
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover.
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