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An Improved Technique for Chromosomal Analysis of Human ES and iPS Cells

Abstract:

Prolonged in vitro culture of human embryonic stem (hES) cells can result in chromosomal abnormalities believed to confer a selective advantage. This potential occurrence has crucial implications for the appropriate use of hES cells for research and therapeutic purposes. In view of this, time-point karyotypic evaluation to assess genetic stability is recommended as a necessary control test to be carried out during extensive 'passaging'. Standard techniques currently used for the cytogenetic a...

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Publisher copy:
10.1007/s12015-010-9224-4

Authors


Journal:
Stem Cell Reviews and Reports More from this journal
Volume:
7
Issue:
2
Pages:
471-477
Publication date:
2011-06-01
DOI:
EISSN:
1558-6804
ISSN:
1550-8943
Language:
English
Keywords:
Pubs id:
pubs:149713
UUID:
uuid:f6d25fc8-61f7-40db-8c6f-9173b6ec1907
Local pid:
pubs:149713
Source identifiers:
149713
Deposit date:
2012-12-19

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