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Optimization of poly(amido amine)s as vectors for siRNA delivery.

Abstract:

By Michael addition polymerization of N,N'-cystaminebisacrylamide (CBA) with variable ratios of 4-amino-1-butanol (ABOL) and ethylene diamine (EDA) or triethylenetetramine (TETA), poly(amido amine) copolymers could be obtained with tunable charge densities. The copolymers were optimized to serve as nonviral vectors in RNA interference (RNAi) to form stable, nanosized polyplexes with siRNA with maximum transfection efficacy. It was observed that at least 20-30% EDA or TETA amino units in the c...

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Authors


van der Aa, LJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Schiffelers, RM More by this author
Engbersen, JF More by this author
Journal:
Journal of controlled release : official journal of the Controlled Release Society
Volume:
150
Issue:
2
Pages:
177-186
Publication date:
2011-03-05
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:f6b67905-7de8-4727-be5d-aeff935333ea
Source identifiers:
345857
Local pid:
pubs:345857

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