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Mechanistic insight into enzymatic glycosyl transfer with retention of configuration through analysis of glycomimetic inhibitors.

Abstract:

(Figure Presented) Structural "valid"-ation: The mechanism of enzyme-catalyzed glycosyl transfer with retention of anomeric configuration continues to baffle, a situation compounded by the lack of insightful 3-D structures of ternary enzyme complexes. Synthesis and multi-dimensional kinetic analysis of validoxylamine derivatives are used to access the 3-D structure of a ternary complex (see picture; U = uridyl) providing insight into the geometry and donor-acceptor interplay at the glycosyltr...

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Publication status:
Published

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Publisher copy:
10.1002/anie.200905096

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Journal:
Angewandte Chemie (International ed. in English)
Volume:
49
Issue:
7
Pages:
1234-1237
Publication date:
2010-02-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:f6b39966-7a05-4758-a33e-9081d8a3c29e
Source identifiers:
45937
Local pid:
pubs:45937

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