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Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification.

Abstract:

In the Drosophila oocyte, mRNA transport and localised translation play a fundamental role in axis determination and germline formation of the future embryo. gurken mRNA encodes a secreted TGF-α signal that specifies dorsal structures, and is localised to the dorso-anterior corner of the oocyte via a cis-acting 64 nucleotide gurken localisation signal. Using GRNA chromatography, we characterised the biochemical composition of the ribonucleoprotein complexes that form around the gurken mRNA lo...

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Publisher copy:
10.1242/bio.2012885

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Biology open More from this journal
Volume:
1
Issue:
5
Pages:
488-497
Publication date:
2012-05-01
DOI:
EISSN:
2046-6390
Language:
English
Keywords:
Pubs id:
pubs:365518
UUID:
uuid:f6af344c-a446-48a8-9a09-7f48e49cdb6c
Local pid:
pubs:365518
Source identifiers:
365518
Deposit date:
2013-11-17

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