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Complex polymorphisms in the Plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response.

Abstract:

Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including the Apicomplexa parasites. P. falciparum genome analysis has revealed two genes coding for the multidrug resistance protein (MRP) type of ABC transporters: Pfmrp1, previously associated with decreased parasite drug susceptibility, and the poorly studied Pfmrp2. The ro...

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Publication status:
Published

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Publisher copy:
10.1128/aac.03337-14

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Publisher:
American Society for Microbiology
Journal:
Antimicrobial agents and chemotherapy
Volume:
58
Issue:
12
Pages:
7390-7397
Publication date:
2014-12-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:f6aa8df7-a206-49e0-8b61-5e9187f2e1bd
Source identifiers:
485471
Local pid:
pubs:485471
Language:
English

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