- Abstract:
-
Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including the Apicomplexa parasites. P. falciparum genome analysis has revealed two genes coding for the multidrug resistance protein (MRP) type of ABC transporters: Pfmrp1, previously associated with decreased parasite drug susceptibility, and the poorly studied Pfmrp2. The ro...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/aac.03337-14
-
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- Publisher:
- American Society for Microbiology
- Journal:
- Antimicrobial agents and chemotherapy
- Volume:
- 58
- Issue:
- 12
- Pages:
- 7390-7397
- Publication date:
- 2014-12-05
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- URN:
-
uuid:f6aa8df7-a206-49e0-8b61-5e9187f2e1bd
- Source identifiers:
-
485471
- Local pid:
- pubs:485471
- Language:
- English
- Copyright date:
- 2014
Journal article
Complex polymorphisms in the Plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response.
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