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Journal article

Digital twins and Big AI: the future of truly individualised healthcare

Abstract:
The integration of physics-based digital twins with data-driven artificial intelligence—termed “Big AI”—can advance truly personalised medicine. While digital twins offer individual ‘healthcasts,’ accuracy and interpretability, and AI delivers speed and flexibility, each has limitations. Big AI combines their strengths, enabling faster, more reliable and individualised predictions, with applications from diagnostics to drug discovery. Above all, Big AI restores mechanistic insights to AI and complies with the scientific method.
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1038/s41746-025-01874-x

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Sub department:
Pathology Dunn School
Role:
Author


Publisher:
Nature Research
Journal:
npj Digital Medicine More from this journal
Volume:
8
Issue:
1
Article number:
494
Publication date:
2025-08-01
Acceptance date:
2025-07-08
DOI:
EISSN:
2398-6352


Language:
English
Source identifiers:
3166377
Deposit date:
2025-08-01
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