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Journal article

Site of action of platelet-activating factor within the mucosa of rabbit distal colon.

Abstract:

1. To determine how platelet-activating factor stimulates colonic anion secretion and increases epithelial permeability, epithelial sheets of rabbit distal colon excluding the submucosal neural plexus were mounted in Ussing chambers. The influence of specific inhibitors and 50 nmol/l platelet-activating factor on short-circuit current and transepithelial resistance was then investigated. 2. Pretreatment with 1 mumol/l indomethacin or 1 mumol/l doxantrazole abolished the biphasic stimulation o...

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Publication status:
Published

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Journal:
Clinical science (London, England : 1979)
Volume:
88
Issue:
1
Pages:
51-57
Publication date:
1995-01-05
EISSN:
1470-8736
ISSN:
0143-5221
URN:
uuid:f6a166b9-c638-4a70-a4fe-c9bd6d0fc19e
Source identifiers:
135481
Local pid:
pubs:135481

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