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Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons.

Abstract:

Glutamate and nitric oxide (NO) are important regulators of dendrite and axon development in the central nervous system. Excess glutamatergic stimulation is a feature of many pathological conditions and manifests in neuronal atrophy and shrinkage with eventual neurodegeneration and cell death. Here we demonstrate that treatment of cultured primary cortical rat neurons for 24 h with glutamate (500 μM) or N-methyl-d-aspartate (NMDA) (100–500 μM) combined with glycine suppresses neurite outgrowt...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Name:
Health Research Board of Ireland
Publisher:
Elsevier
Journal:
Neuroscience More from this journal
Volume:
301
Pages:
421-438
Publication date:
2015-08-01
DOI:
ISSN:
0306-4522
Keywords:
Pubs id:
pubs:546988
UUID:
uuid:f69d51b5-0fa8-48b4-b69a-4d2bf194ad92
Local pid:
pubs:546988
Source identifiers:
546988
Deposit date:
2015-11-27

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