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A model for chondrogenic condensations in the developing limb: the role of extracellular matrix and cell tractions.

Abstract:

The hyaluronate component of the extracellular matrix is a powerfully hydrophilic polymer, capable of osmotically swelling and deswelling by a volume factor of 5 or more. At the time of cartilage condensation in the limb bud the chondrocytes start to produce hyaluronidase, an enzyme which degrades hyaluronate. The consequent deswelling brings the chondrocytes closer together - close enough for intercellular cell tractions to become effective and intercellular junctions to form. By analysing t...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
Journal:
Journal of embryology and experimental morphology
Volume:
89
Issue:
OCT
Pages:
93-112
Publication date:
1985-10-01
ISSN:
0022-0752
Source identifiers:
22568
Language:
English
Keywords:
Pubs id:
pubs:22568
UUID:
uuid:f68eb8d4-e61b-4f56-8eb8-58093d45e133
Local pid:
pubs:22568
Deposit date:
2012-12-19

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